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R 59-022 hydrochloride
CAS No. 93076-98-3
R 59-022 hydrochloride( —— )
Catalog No. M36453 CAS No. 93076-98-3
R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 273 | In Stock |
|
| 50MG | 440 | In Stock |
|
| 100MG | 619 | In Stock |
|
| 500MG | 1278 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameR 59-022 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionR 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).
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DescriptionR 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 μM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
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In VitroWestern Blot Analysis Cell Line:HeLa cells Concentration:40 uM Incubation Time:30 min Result:Increased the phosphorylation of PKC downstream targets by about 2.5-fold.
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In VivoAnimal Model:SCID mice implanted with U87 GBM cells Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increased median survival and decreased tumor volume.
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Synonyms——
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC | 5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number93076-98-3
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Formula Weight496.04
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Molecular FormulaC27H27ClFN3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (50.40 mM; Ultrasonic )
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SMILESCl.O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de Chaffoy de Courcelles, D.C., et al. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J. Biol. Chem. 260(29), 15762-15770 (1985). ?
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